Pyoderma Gangrenosum
Pyoderma gangrenosum is a necrotizing skin disease .It may appear as a blister on the legs or arms, usually at the site of a minor trauma such as a cut. The lesions are painful and occur mostly on the lower extremities, either single or multiple, but can appear in any region of the body. Pyoderma gangrenosum is a rare condition of unknown etiology that was described as an extra intestinal manifestation of inflammatory bowel disease including crohn's disease in 1930.
Pyoderma gangrenosum is a rare skin disease. At present, there are few well-designed published studies that help determine the optimal therapeutic strategy to use for the management of this illness. Dermatologist considers it as relatively uncommon dermatosis characterised by chronic, recurring ulcerations with distinctive clinical features. Despite it's association with numerous systemic diseases in 50 percent of cases, the pathogenesis is still uncertain and the treatment, a challenge.
Treatment includes wound care, antibiotics, corticosteroids, and immunomodulators. However, response to therapy varies, and many patients with pyoderma gangrenosum have disease that is refractory to these agents. It mainly affects children and young adults.
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Skin-Cancer Article Source: http://www.eArticlesOnline.com
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